GOSSIP & RUMORS: What is POTS, disorder affecting Christina Applegate’s daughter Sadie?

Christina Applegate’s 13-year-old daughter Sadie Grace LeNoble revealed this week that she has been diagnosed with postural orthostatic tachycardia syndrome, also known as POTS.

On Tuesday’s episode of Applegate’s “MeSsy” podcast, Sadie opened up about her condition, “I have something called POTS. I have no clue what it actually is, but it’s something to do with the autonomic nervous system and it affects my heart. When I stand up, I get really, really dizzy and my legs get really weak and I feel like I’m going to pass out.”

Sadie said her diagnosis has given her newfound compassion for and common ground with her mom, 52, who has multiple sclerosis.

What is POTS?

According to Johns Hopkins Medicine, POTS is a chronic disorder that affects the autonomic nervous system and blood circulation. It’s characterized by an extreme increase in heart rate when a person is standing.

Although POTS is part of the broader category of dysautonomia, a disorder of the autonomic nervous system, POTS specifically involves the cardiovascular system’s response to standing up from a reclined position.

What are the symptoms?

Symptoms of POTS include brain fog, fatigue, lightheadedness, fainting, headaches, blurry vision, palpitations, excessive sweat, pallor, intolerance of physical activity, tremors and nausea.

Symptoms of POTS worsen in warm environments, situations that require a lot of standing. Dehydration, hunger, and a common cold or infection also exacerbate symptoms of POTS.

In some cases, POTS symptoms are so severe a person cannot be upright for more than a few minutes at a time, seriously affecting quality of life.

Sadie — whom Applegate shares with her husband, Martyn LeNoble — recalled visiting the school nurse several times a day as a sixth grader. “In class, if I were to stand up then, I would be like, ‘I have to go to the nurse. I can’t do this.’ Or I’ll be in PE, and I’ll be like, ‘I have to go to the nurse,’” she said.

“They were like, ‘You’re doing this to get out of class. It’s probably just anxiety. Go back to class.’ They wouldn’t do anything for it,” she added.

Sadie’s experience mirrors the misdiagnosis of POTS, as the symptoms are often incorrectly attributed to psychological disorders such as anxiety.

What causes POTS?

POTS may develop or present itself during puberty, after a viral illness, or following surgery or other major medical events.

Some researchers believe that COVID-19 can be a trigger for POTS, as an increased number of people who recovered from the virus are experiencing POTS-like symptoms, such as chronic fatigue, brain fog, and increased heart rate.

While POTS can run in families, no single gene has been identified. In terms of genetic factors, there is a strong relationship between POTS and various joint hypermobility disorders, including Ehlers-Danlos syndrome.

Is POTS treatable?

Johns Hopkins notes that POTS is not life-threatening, but a major risk is falling from fainting.

While there is no known cure for POTS, symptoms can be treated with a combination of diet, medications, exercise and physical therapy.

How common is the syndrome?

POTS affects an estimated 1 million to 3 million Americans, and while physicians and researchers don’t fully understand what causes POTS, it is more common in women and typically develops in adolescents and young adults, specifically during puberty.

POTS is diagnosed with a 10-minute standing test or a table tilt test.

Have any other celebrities been diagnosed with POTS?

Celebrities who have shared their POTS diagnoses include musician Halsey, who detailed their journey in an interview with Vanity Fair.

Tori Moore Foles, the wife of NFL quarterback Nick Foles, has also been open about her POTS diagnosis.

Reality TV vet and Skinnygirl entrepreneur Bethenny Frankel has been very candid about her daily struggles with POTS.

She attributes the worsening of her symptoms to long COVID.